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✔ Proof-Based mostly. Scientifically Reviewed by Michael Sharpe, MSc and Dr. Michael Tamber, MD.

Dimethylnandrolone Undecanoate (DMAU), Trestolone (MENT), and 11-methyl-19-nortestosterone (11-MNT) are sister chemical substances being studied as a male contraceptive tablet and as testosterone alternative.

Dimethandrolone (DMA), additionally identified by its assigned code title CDB-1321 or as DMAU in its undecanoate esterified type, is an investigational progestogen and androgenic anabolic steroid (AAS) that’s being researched for attainable therapeutic software.

Compared to trestolone, DMAU is a superior alternative for hormone alternative, in response to researchers. Trestolone has a really quick half life. (1, 2, 3)

As well as, DMAU limits sperm manufacturing however doesn’t decrease libido or intrude with ejaculation, in response to outcomes from earlier research. (2, 3)

• DMAU is in growth as a male contraceptive.
• 2019 Part I human scientific research have been profitable and it was deemed non-toxic and well-tolerated.
• After cessation, spermatogenesis returns rapidly.
• Will be orally-administered or given as injection.
• Doesn’t have aromatase motion.
• DMAU is 136 instances extra myotrophic than testosterone. It’s anabolic than its sister chemical substances trestolone (MENT) and 11β-methyl-19-nortestosterone (11β-MNT).

DMAU as a Male Contraceptive

On the most studied dose of DMAU, 400 mg, people had marked discount of ranges of the sperm-producing hormones LH, FSH, and testosterone. (4)

Regardless of having low circulating testosterone ranges, solely a small variety of individuals confirmed signs related to both extra or insufficiency of testosterone.

Research

Eighty-two individuals attended the trial. There have been no important detrimental outcomes. Security laboratory measurements didn’t alter in a clinically related manner. (5)

Every day oral administration of DMAU for 28 days in wholesome males is properly tolerated. Doses of ≥200 mg considerably suppressed serum testosterone, LH, and FSH. (5)

Androgen Substitute

In keeping with the entire knowledge collected, androgen alternative with DMAU or 11-MNTDC in Cx rats led to helpful alterations in physique composition.

The upkeep of carried out mineral density that was equal to that of testosterone. (6)

Does Not 5α-Reductase

DMAU is just not vulnerable to metabolism by the 5-reductase enzyme. (7)

The perform of 5-reduction within the androgenic exercise of DMA and MNT was investigated since 5-reduced androgens, akin to DHT, might enhance the danger of benign prostate hyperplasia, hasten the event of prostate most cancers, and enhance male sample baldness and zits. (7)

In keeping with the findings, inhibiting the exercise of 5-reductase in vivo has no impact on the androgenic efficacy of DMA, MNT, or MENT. (7)

Does Not Appear to Aromatase

The chance of shoppers experiencing oestrogenic hostile results is zero, declare specialists on the US-based Bioqual. Dimethandrolone didn’t convert into oestrogenic substances throughout assessments in check tubes. (8)

References

This part incorporates hyperlinks to analysis, research, and sources of data for this text, in addition to authors, contributors, and so forth. All sources, together with the article and info, are subjected to a sequence of high quality, reliability, and relevance checks.

Actual Muscle primarily makes use of high-quality sources, akin to peer-reviewed publications, to again up the data in our articles. To know extra about how we fact-check and hold our data correct, reliable, and reliable, learn extra about us.

This evidence-based evaluation of Dimethylnandrolone Undecanoate (DMAU) options 8 references, listed under.

1. Attardi BJ, Hild SA, Reel JR. Dimethandrolone undecanoate: a brand new potent orally energetic androgen with progestational exercise. Endocrinology. (2006)

2. Walton, Melanie J., et al. 7α-methyl-19-nortestosterone (MENT) vs Testosterone in Mixture With Etonogestrel Implants for Spermatogenic Suppression in Wholesome Males. Journal of Andrology. (2007)

3. Kumar N, Suvisaari J, Tsong YY, et al. Pharmacokinetics of seven alpha-methyl-19-nortestosterone in males and cynomolgus monkeys. J Androl. (1997)

4. Dimethandrolone Undecanoate Exhibits Promise as a Male Start Management Tablet

5. Thirumalai A, Ceponis J, Amory JK, et al. Results of 28 Days of Oral Dimethandrolone Undecanoate in Wholesome Males: A Prototype Male Tablet. J Clin Endocrinol Metab. (2019) (Medical Trial)

6. Attardi BJ, Marck BT, Matsumoto AM, Koduri S, Hild SA. Lengthy-term results of dimethandrolone 17β-undecanoate and 11β-methyl-19-nortestosterone 17β-dodecylcarbonate on physique composition, bone mineral density, serum gonadotropins, and androgenic/anabolic exercise in castrated male rats. J Androl. (2011)

7. Attardi BJ, Hild SA, Koduri S, et al. The potent artificial androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, don’t require 5α-reduction to exert their maximal androgenic results. J Steroid Biochem Mol Biol. (2010)

8. Monster anabolic dimethandrolone doesn’t aromatize

The knowledge supplied on this article is just not supposed to switch skilled medical recommendation, analysis, or therapy. All the time search the steering of a doctor or different competent skilled earlier than following recommendation or taking any complement. See our phrases and circumstances.

We strictly don’t advise anybody to make use of, or think about using, any exogenous hormone or chemical akin to trestolone, except suggested or prescribed to take action by a certified physician. Doing so might lead to severe and long-term hostile results.

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